Mechanical LINCs of the nuclear envelope: Where SUN meets KASH
نویسندگان
چکیده
منابع مشابه
Connecting the nucleus to the cytoskeleton by SUN-KASH bridges across the nuclear envelope.
The nuclear-cytoskeleton connection influences many aspects of cellular architecture, including nuclear positioning, the stiffness of the global cytoskeleton, and mechanotransduction. Central to all of these processes is the assembly and function of conserved SUN-KASH bridges, or LINC complexes, that span the nuclear envelope. Recent studies provide details of the higher order assembly and targ...
متن کاملInteractions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges.
The nuclear envelope links the cytoskeleton to structural components of the nucleus. It functions to coordinate nuclear migration and anchorage, organize chromatin, and aid meiotic chromosome pairing. Forces generated by the cytoskeleton are transferred across the nuclear envelope to the nuclear lamina through a nuclear-envelope bridge consisting of SUN (Sad1 and UNC-84) and KASH (Klarsicht, AN...
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KASH and SUN proteins Quick guides at-bat, including which fielders were involved, and so on. At that point, I was amused to see that my friend Kyle was also keeping score, but that he marked every at-bat with a simple and uninformative ‘X’ when each batter was retired; consequently, his whole data sheet on the opposing team was just one string of Xs after another. Although I was feeling the su...
متن کاملSUN proteins and nuclear envelope spacing
The nuclear envelope consists of 2 membranes separated by 30-50 nm, but how the 2 membranes are evenly spaced has been an open question in the field. Nuclear envelope bridges composed of inner nuclear membrane SUN proteins and outer nuclear membrane KASH proteins have been proposed to set and regulate nuclear envelope spacing. We tested this hypothesis directly by examining nuclear envelope spa...
متن کاملA new SUN role – no KASH required?
In eukaryotic cells, a close physical association between the microtubule-organising centre (MTOC) and the nucleus is essential, and its disruption leads to severe cellular abnormalities. MTOC–nucleus attachment is maintained by SUN and KASH proteins, which are found in the inner and outer nuclear membranes, respectively, and typically interact to form nuclear-envelope-spanning LINC complexes. ...
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ژورنال
عنوان ژورنال: Extreme Mechanics Letters
سال: 2018
ISSN: 2352-4316
DOI: 10.1016/j.eml.2018.01.010